That 160 sign just west of the I-25/CO 10 interchange had a 10 sign on it about a year before the photo you linked, which may have just fallen off. It seems signage would support calling it CO 10 if that's what you want to do. I agree with moving 160 off that segment.
That was my gut thought (extend CO 10 to the business loop), but I wanted to see if anyone else had any other ideas. If no one objects, I'll extend CO 10 based on the tenuous signage (hey, it's better than nothing, right?).